United States securities and exchange commission logo May 18, 2021 Chen Schor President and Chief Executive Officer Adicet Bio, Inc. 500 Boylston Street, 13th Floor Boston, MA 02116 Re: Adicet Bio, Inc. Registration Statement on Form S-3 Filed May 13, 2021 File No. 333-256088 Dear Mr. Schor: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact Jason L. Drory at 202-551-8342 with any questions. Sincerely, Division of Corporation Finance Office of Life Sciences cc: Gabriela Morales-Rivera, Esq.